Subtilin Production byBacillus Subtilis: Stochastic Hybrid Models and Parameter Identification
نویسندگان
چکیده
منابع مشابه
Subtilin Production by Bacillus Subtilis: Stochastic Hybrid Models and Parameter Identification
This paper presents methods for the parameter identification of a model of subtilin production by Bacillus subtilis. Based on a stochastic hybrid model, identification is split in two subproblems: estimation of the genetic network regulating subtilin production from gene expression data, and estimation of population dynamics based on nutrient and population level data. Techniques for identifica...
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The genetic network regulating the biosynthesis of subtilin in Bacillus subtilis is modeled as a stochastic hybrid system. The continuous state of the hybrid system is the concentrations of subtilin and various regulating proteins, whose productions are controlled by switches in the genetic network that are in turn modeled as Markov chains. Some preliminary results are given by both analysis an...
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ژورنال
عنوان ژورنال: IEEE Transactions on Automatic Control
سال: 2008
ISSN: 0018-9286
DOI: 10.1109/tac.2007.911327